Negative regulation of humoral immune response mediated by circulating immunoglobulin

Across TCGA patient cohorts, RNA activity of the Negative regulation of humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS33, IFFO1, and STAB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of humoral immune response mediated by circulating immunoglobulin activity versus MRPS33 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPS33 →	-0.277	-0.140	.001	.005	3	5
OV	IFFO1 →	+0.752	+0.190	<.001	<.001	3	5
OV	STAB1 →	+0.961	+0.158	<.001	<.001	3	5
GBM	CDCA7L →	-0.590	-0.591	.009	.002	3	5
LUAD	PSMD10 →	-0.347	-0.195	.001	.005	3	4
LUAD	COX6A1 →	-0.310	-0.140	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002924 vs MRPS33 — LUAD

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