Negative regulation of humoral immune response mediated by circulating immunoglobulin

Across TCGA cell cohorts, RNA activity of the Negative regulation of humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOC2L, SPATA18, and MAP2K4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOC2L grouped by Negative regulation of humoral immune response mediated by circulating immunoglobulin-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NOC2L →	+1.252	+1.149	.009	.003	3	5
SOFT_TISSUE	SPATA18 →	+1.828	+1.144	<.001	.009	3	5
LUNG_SCLC	MAP2K4 →	-0.835	-1.382	<.001	<.001	3	4
PANCREAS	ZBTB49 →	+0.502	+0.899	<.001	.002	3	4
PANCREAS	ZNF721 →	+0.630	+0.814	.003	.004	3	4
PANCREAS	EWSR1 →	+0.456	+0.878	.006	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOC2L by Negative regulation of humoral immune response mediated by circulating immunoglobulin activity — LUNG_SCLC

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