Positive regulation of humoral immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF324, PTDSS1, and ZNF814, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF324 grouped by Positive regulation of humoral immune response-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF324 →	+0.501	+1.163	.002	.004	3	5
BONE	PTDSS1 →	+1.173	+1.414	.006	.009	3	4
BLOOD_Myeloma	ZNF814 →	+1.186	+0.811	<.001	.004	3	4
BLOOD_Leukemia	RCC1 →	+0.642	+0.889	.002	.001	3	4
BLOOD_Leukemia	PTPN11 →	+0.736	+0.910	.006	.001	3	4
SKIN	TTLL1 →	-0.966	-0.879	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF324 by Positive regulation of humoral immune response activity — BONE

Explore this box plot interactively →