Negative regulation of humoral immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of humoral immune response pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C4BPA, C8G, and CD55, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of humoral immune response activity versus C4BPA in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4BPA →	+0.844	+0.213	<.001	<.001	3	6
CCRCC	C8G →	+0.560	+0.217	<.001	<.001	3	6
OV	CD55 →	+0.834	+0.233	<.001	<.001	3	6
OV	HPX →	+0.535	+0.224	<.001	.001	2	7
CCRCC	ITIH4 →	+0.416	+0.149	<.001	<.001	3	6
CCRCC	KNG1 →	+0.543	+0.212	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002921 vs C4BPA — UCEC

Explore this scatter interactively →