Regulation of humoral immune response

Across TCGA cell cohorts, RNA activity of the Regulation of humoral immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3M, ACADVL, and FMNL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of humoral immune response activity versus EIF3M in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF3M →	+0.472	+0.136	.001	.004	2	6
SOFT_TISSUE	ACADVL →	+0.761	+0.279	.008	.001	3	4
LUNG_SCLC	FMNL2 →	+1.340	+0.182	.002	.006	2	5
LUNG_SCLC	VCP →	-0.654	-0.255	<.001	.001	3	4
BLOOD_Leukemia	FAM234A →	-0.430	-0.125	.007	.002	3	4
BREAST	TAF4B →	-1.069	-0.331	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002920 vs EIF3M — BLOOD_Leukemia

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