Regulation of myeloid leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of myeloid leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PICALM, TMX1, and ZDHHC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PICALM grouped by Regulation of myeloid leukocyte mediated immunity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PICALM →	-0.557	-0.530	.005	.005	3	4
BREAST	TMX1 →	-0.690	-0.276	.006	<.001	3	3
BREAST	ZDHHC18 →	-0.771	-0.384	<.001	.009	3	3
CNS	GLRB →	-0.987	-0.500	<.001	.008	3	3
OESOPHAGUS	TFPI2 →	-2.791	-0.277	.001	.006	3	3
LARGE_INTESTINE	RALY →	-0.790	-0.788	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PICALM by Regulation of myeloid leukocyte mediated immunity activity — LARGE_INTESTINE

Explore this box plot interactively →