Positive regulation of natural killer cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Positive regulation of natural killer cell mediated immune response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1_S218, EIF2S1, and MTR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell mediated immune response to tumor cell activity versus LSP1_S218 in COAD (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LSP1_S218 →	-0.418	-0.091	<.001	<.001	3	6
OV	EIF2S1 →	+0.206	+0.056	<.001	.004	3	5
LUAD	MTR →	-0.311	-0.079	<.001	<.001	3	5
LSCC	TIMM50 →	+0.320	+0.045	.007	.003	2	6
LSCC	PITHD1 →	-0.193	-0.043	.008	.001	3	5
UCEC	RPS8 →	+0.286	+0.094	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002857 vs LSP1_S218 — COAD

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