Positive regulation of T cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, MTCO2P16, and LINC02693, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated immune response to tumor cell activity versus SMO in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMO →	-0.982	-0.582	.002	.006	3	4
CCRCC	MTCO2P16 →	-0.415	-0.439	.006	.009	2	4
PDAC	LINC02693 →	-0.184	-0.079	.001	.002	3	3
PDAC	CASC15 →	-0.296	-0.074	.006	.004	3	3
GBM	TRAJ31 →	+0.855	+0.518	.006	.005	3	3
BRCA	ARAP3 →	-0.547	-0.443	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002842 vs SMO — BRCA

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