Positive regulation of T cell mediated immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAG, ITGB4, and UBE3C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated immune response to tumor cell activity versus YWHAG in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	YWHAG →	+0.877	+0.117	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	ITGB4 →	-1.390	-0.125	.006	<.001	2	5
LARGE_INTESTINE	UBE3C →	+0.763	+0.164	<.001	.001	3	4
LUNG_NSCLC_LUAD	ZNF174 →	+0.410	+0.124	.007	.006	3	4
LIVER	DAPK1 →	-3.179	-0.116	.006	.008	3	4
BLOOD_Lymphoma	TMSB10 →	+1.509	+0.207	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002842 vs YWHAG — BREAST

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