Regulation of T cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK2, KCTD12, and LPXN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immune response to tumor cell activity versus DOCK2 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOCK2 →	+0.520	+0.105	<.001	<.001	3	9
UCEC	KCTD12 →	+0.450	+0.072	<.001	.002	3	9
LSCC	LPXN →	+0.490	+0.097	<.001	<.001	3	9
LSCC	ARHGAP25 →	+0.527	+0.098	<.001	<.001	3	9
UCEC	DOCK10 →	+0.464	+0.083	<.001	<.001	3	9
GBM	FKBP15 →	+0.190	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002840 vs DOCK2 — GBM

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