Regulation of T cell mediated immune response to tumor cell

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of T cell mediated immune response to tumor cell pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Regulation of T cell mediated immune response to tumor cell pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and BLCA, show the opposite pattern, with higher activity associated with better survival.

SKCM, BLCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.479	0.243	<.001	120	view →
BLCA	OS	Median	All	0.519	0.345	<.001	113	view →
UVM	DFS	Tertile	III,IV	0.289	0.818	<.001	87	view →
KIRP	OS	Quartile	II,III,IV	0.120	0.940	<.001	75	view →
LGG	OS	Median	All	0.740	0.865	<.001	44	view →
KIRC	OS	Tertile	All	0.556	0.718	<.001	36	view →
GBM	DFS	Quartile	All	0.110	0.471	<.001	29	view →
OV	DFS	Quartile	IV	0.296	0.655	.002	26	view →
MESO	OS	Quartile	All	0.649	0.384	.005	22	view →
SCLC	OS	Tertile	III,IV	0.789	0.356	.006	20	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.248	.018	18	view →
LUAD	DFS	Median	All	0.716	0.619	.016	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0002840–SKCM (OS)

Open the SKCM breakdown →