Regulation of T cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1G, HLA-DMA, and LAIR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immune response to tumor cell activity versus MYO1G in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1G →	+1.311	+0.204	<.001	<.001	3	6
HNSC	HLA-DMA →	+1.071	+0.215	<.001	.007	3	6
GBM	LAIR1 →	+1.569	+0.342	<.001	.001	3	6
GBM	FPR3 →	+1.051	+0.230	<.001	.006	3	6
HNSC	CD80 →	+0.528	+0.170	.006	<.001	3	6
LSCC	TYROBP →	+0.621	+0.127	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002840 vs MYO1G — GBM

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