Regulation of T cell mediated immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF837, PCCB, and ADAM15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF837 grouped by Regulation of T cell mediated immune response to tumor cell-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF837 →	-1.284	-0.315	<.001	.004	3	5
PANCREAS	PCCB →	+0.560	+0.260	.002	<.001	3	4
STOMACH	ADAM15 →	+0.849	+0.377	.007	.003	3	4
PANCREAS	TEX29 →	-0.171	-0.339	.001	<.001	3	3
SKIN	VPS35L →	+0.890	+0.136	<.001	.004	3	3
LUNG_NSCLC_LUSC	LMBRD1 →	-1.176	-0.303	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF837 by Regulation of T cell mediated immune response to tumor cell activity — BONE

Explore this box plot interactively →