Regulation of T cell mediated immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHB2, LTV1, and MLF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immune response to tumor cell activity versus PHB2 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PHB2 →	+0.989	+0.185	.008	<.001	3	6
LIVER	LTV1 →	+1.061	+0.215	.005	<.001	3	5
BREAST	MLF2 →	+0.835	+0.187	<.001	<.001	3	5
KIDNEY	HASPIN →	+1.071	+0.146	<.001	.006	3	5
LIVER	DDX23 →	+0.582	+0.227	.001	<.001	3	5
LUNG_SCLC	MRPL51 →	+0.771	+0.129	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002840 vs PHB2 — LUNG_SCLC

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