Negative regulation of response to tumor cell

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, SASH3, and SAMSN1_S23, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to tumor cell activity versus SKAP2 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.804	+0.123	<.001	<.001	3	10
UCEC	SASH3 →	+0.596	+0.123	<.001	<.001	3	10
GBM	SAMSN1_S23 →	+0.737	+0.123	<.001	<.001	3	10
OV	THEMIS2_T593 →	+1.053	+0.118	.001	<.001	3	10
GBM	AIF1 →	+0.888	+0.125	<.001	<.001	3	10
GBM	FERMT3 →	+0.706	+0.119	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002835 vs SKAP2 — GBM

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