Negative regulation of response to tumor cell

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of response to tumor cell pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Negative regulation of response to tumor cell pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCEC, show the opposite pattern, with higher activity associated with better survival.

HNSC, UCEC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.483	0.148	<.001	122	view →
UCEC	DFS	Quartile	All	0.719	0.495	<.001	96	view →
SKCM	OS	Median	All	0.429	0.260	<.001	96	view →
KIRP	DFS	Median	II,III,IV	0.168	0.842	.001	72	view →
LUAD	DFS	Median	II,III,IV	0.557	0.315	.002	61	view →
GBM	OS	Quartile	All	0.268	0.655	.001	30	view →
BLCA	OS	Median	II,III,IV	0.765	0.671	.015	29	view →
UVM	DFS	Quartile	All	0.332	0.681	.004	25	view →
CESC	DFS	Tertile	All	0.832	0.661	.002	24	view →
ACC	OS	Quartile	All	0.896	0.241	.001	21	view →
MESO	OS	Quartile	All	0.833	0.270	.006	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0002835–HNSC (DFS)

Open the HNSC breakdown →