Negative regulation of response to tumor cell

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to tumor cell pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRU, ZBTB39, and MCM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRU grouped by Negative regulation of response to tumor cell-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PTPRU →	+0.226	+0.153	.009	.001	3	4
OESOPHAGUS	ZBTB39 →	+0.143	+0.163	.005	<.001	3	4
STOMACH	MCM2 →	+0.261	+0.154	.008	.001	3	4
LUNG_SCLC	KLHL18 →	-0.248	-0.206	.005	<.001	3	4
BREAST	NLRP12 →	+0.116	+0.155	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	OLIG3 →	-0.155	-0.124	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRU by Negative regulation of response to tumor cell activity — BONE

Explore this box plot interactively →