Negative regulation of response to tumor cell

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM174B, TJP3, and PLCXD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to tumor cell activity versus FAM174B in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM174B →	+2.309	+0.236	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TJP3 →	+1.550	+0.161	<.001	.001	3	4
LUNG_NSCLC_LUAD	PLCXD1 →	+1.534	+0.201	.001	.001	3	4
LUNG_SCLC	GPD1 →	+0.870	+0.188	<.001	<.001	3	4
LUNG_NSCLC_LUSC	TSPAN33 →	+2.432	+0.419	.009	.008	3	4
LUNG_NSCLC_LUSC	S100A2 →	-5.168	-0.413	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002835 vs FAM174B — BREAST

Explore this scatter interactively →