Negative regulation of response to biotic stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGAS, ZNF555, and BCL2A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to biotic stimulus activity versus CGAS in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CGAS →	+1.046	+0.125	<.001	.003	3	7
HNSC	ZNF555 →	-0.375	-0.110	.007	.001	3	7
CCRCC	BCL2A1 →	+1.174	+0.177	<.001	<.001	3	7
BRCA	EZH1 →	-0.684	-0.185	<.001	<.001	3	6
BRCA	VIPR1 →	-1.268	-0.208	<.001	<.001	3	6
HNSC	NMI →	+0.765	+0.203	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002832 vs CGAS — OV

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