Positive regulation of T-helper 1 type immune response

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, RIPK2, and MOAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 1 type immune response activity versus PLA2G4A in UCEC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+2.057	+0.548	<.001	.005	3	7
BRCA	RIPK2 →	+0.599	+0.528	<.001	<.001	3	6
CCRCC	MOAP1 →	-0.597	-1.109	<.001	<.001	3	5
UCEC	TMEM63C →	-0.498	-0.418	.004	.001	3	5
BRCA	IL27 →	+0.418	+0.611	.001	<.001	3	5
CCRCC	LILRB1 →	+0.694	+0.923	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002827 vs PLA2G4A — UCEC

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