Negative regulation of T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT5, CACNA2D1, and LY75, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCT5 grouped by Negative regulation of T-helper 1 type immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCT5 →	-0.551	-0.739	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CACNA2D1 →	-2.320	-1.783	<.001	.001	3	4
BLOOD_Lymphoma	LY75 →	+2.876	+1.717	.002	<.001	3	4
LUNG_SCLC	TMEM121 →	+1.927	+1.234	<.001	.002	3	3
BREAST	MDH1B →	+0.607	+0.839	.004	.004	3	3
KIDNEY	UFC1 →	+0.576	+0.979	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT5 by Negative regulation of T-helper 1 type immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →