Positive regulation of adaptive immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of adaptive immune response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-C, and B2M, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adaptive immune response activity versus HLA-B in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HLA-B →	+4.625	+0.251	<.001	.001	3	15
CNS	HLA-C →	+3.800	+0.464	<.001	<.001	3	12
CNS	B2M →	+1.956	+0.384	.002	.003	2	13
BREAST	HLA-A →	+3.686	+0.354	<.001	<.001	3	12
OESOPHAGUS	PSMB8 →	+2.721	+0.192	.007	.007	2	11
PANCREAS	HLA-F →	+3.341	+0.339	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002821 vs HLA-B — STOMACH

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