Regulation of adaptive immune response

Across TCGA cell cohorts, RNA activity of the Regulation of adaptive immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLRG1, ATRX, and STK17A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLRG1 grouped by Regulation of adaptive immune response-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLRG1 →	-0.576	-0.070	.001	.003	3	6
LUNG_SCLC	ATRX →	+0.312	+0.076	.003	.002	3	6
STOMACH	STK17A →	-0.219	-0.040	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RGR →	+0.121	+0.090	.003	<.001	3	5
LUNG_SCLC	ATN1 →	-0.203	-0.086	.001	.002	3	4
LUNG_SCLC	MBD3L1 →	-0.393	-0.074	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLRG1 by Regulation of adaptive immune response activity — LUNG_SCLC

Explore this box plot interactively →