Regulation of adaptive immune response

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of adaptive immune response pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 208 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Regulation of adaptive immune response pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and SKCM, show the opposite pattern, with higher activity associated with better survival.

LUAD, SKCM, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.722	0.310	<.001	87	view →
SKCM	OS	Median	All	0.430	0.273	<.001	85	view →
HNSC	DFS	Tertile	III,IV	0.717	0.501	<.001	78	view →
KIRC	OS	Median	All	0.543	0.682	<.001	64	view →
KIRP	DFS	Quartile	All	0.532	0.886	.001	60	view →
UVM	DFS	Quartile	All	0.332	0.726	<.001	57	view →
LGG	DFS	Median	All	0.614	0.811	<.001	54	view →
LAML	DFS	Quartile	All	0.268	0.574	.002	36	view →
ESCA	OS	Median	III,IV	0.584	0.320	.005	31	view →
PAAD	OS	Median	All	0.529	0.427	.017	30	view →
GBM	OS	Quartile	All	0.195	0.523	<.001	27	view →
CESC	OS	Tertile	II,III,IV	0.929	0.726	.010	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0002819–LUAD (OS)

Open the LUAD breakdown →