Positive regulation of antibacterial peptide production

pathway activity — cross-omics
GO:0002803Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of antibacterial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMCX5, RAB2B, and GGT4P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCARMCX5 →-0.590-0.329.003.00433
LSCCRAB2B →-0.437-0.264<.001.00433
PDACGGT4P →+0.393+0.955.001.00532
PDACCASZ1 →+0.769+1.306.002<.00132
PDACALX3 →+0.146+1.496<.001<.00132
PDACPADI4 →+0.361+1.202<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration