Regulation of antibacterial peptide production

Across TCGA patient cohorts, RNA activity of the Regulation of antibacterial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVPL, SPINK5, and C1orf116, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antibacterial peptide production activity versus EVPL in ESCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	EVPL →	+1.385	+0.138	<.001	<.001	3	20
ESCA	SPINK5 →	+3.206	+0.202	<.001	<.001	3	16
SCLC	C1orf116 →	+1.193	+0.486	<.001	<.001	3	16
HNSC	NSL1 →	-0.631	-0.125	<.001	<.001	3	16
THYM	TACSTD2 →	+2.411	+0.140	<.001	.003	3	16
BLCA	TTC22 →	+0.913	+0.087	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002786 vs EVPL — ESCA

Explore this scatter interactively →