Regulation of antibacterial peptide production

Across TCGA cell cohorts, RNA activity of the Regulation of antibacterial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-A, INAFM2, and RAP1GDS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-A grouped by Regulation of antibacterial peptide production-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HLA-A →	+1.716	+1.437	.004	.007	3	4
KIDNEY	INAFM2 →	-1.041	-1.388	.006	.002	3	4
SKIN	RAP1GDS1 →	-0.634	-0.885	.006	.007	3	4
CNS	LTBP2 →	+1.528	+0.965	.008	.003	3	3
BONE	SLC25A14 →	+0.745	+1.281	.004	.002	3	3
BONE	GRK4 →	+1.449	+2.148	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-A by Regulation of antibacterial peptide production activity — KIDNEY

Explore this box plot interactively →