Regulation of antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Regulation of antimicrobial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVPL, SPINK5, and TACSTD2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antimicrobial peptide production activity versus EVPL in CHOL (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	EVPL →	+3.092	+0.267	<.001	.009	1	21
ESCA	SPINK5 →	+3.132	+0.221	<.001	<.001	3	17
THYM	TACSTD2 →	+2.319	+0.150	<.001	.002	3	17
HNSC	KLK7 →	+3.582	+0.193	<.001	<.001	3	16
HNSC	NSL1 →	-0.633	-0.133	<.001	<.001	3	16
LUAD	C1orf116 →	+1.169	+0.079	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002784 vs EVPL — CHOL

Explore this scatter interactively →