Regulation of antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Regulation of antimicrobial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1, KLK7, and CBFA2T2_S577, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antimicrobial peptide production activity versus TP53BP1 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TP53BP1 →	-0.271	-0.111	<.001	<.001	3	5
LSCC	KLK7 →	+1.426	+0.216	<.001	<.001	2	6
HNSC	CBFA2T2_S577 →	-0.705	-0.218	.001	<.001	3	5
HNSC	CLIC3 →	+0.725	+0.168	<.001	<.001	3	5
GBM	BCL10 →	+0.234	+0.618	.002	.005	3	5
UCEC	ANXA1 →	+0.932	+0.613	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002784 vs TP53BP1 — OV

Explore this scatter interactively →