Regulation of antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Regulation of antimicrobial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DST-AS1, CHORDC1, and CLIC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antimicrobial peptide production activity versus DST-AS1 in HNSC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DST-AS1 →	-0.789	-0.995	<.001	<.001	3	4
LSCC	CHORDC1 →	-0.442	-0.682	.007	.004	3	3
HNSC	CLIC3 →	+1.144	+1.128	<.001	<.001	3	3
HNSC	POGLUT1 →	-0.469	-0.831	.003	<.001	3	3
BRCA	TRAJ10 →	-0.634	-0.508	.008	.005	3	3
HNSC	KLK13 →	+1.385	+0.810	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002784 vs DST-AS1 — HNSC

Explore this scatter interactively →