Regulation of antimicrobial peptide production

Across TCGA cell cohorts, RNA activity of the Regulation of antimicrobial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGPS2, RIPK1, and ZSWIM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RALGPS2 grouped by Regulation of antimicrobial peptide production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RALGPS2 →	-0.797	-0.996	.005	.001	3	4
BREAST	RIPK1 →	-0.646	-1.102	.004	<.001	3	4
OESOPHAGUS	ZSWIM4 →	+0.921	+1.244	.002	.005	3	4
OESOPHAGUS	C16orf46 →	+0.461	+1.182	.006	.004	3	4
LARGE_INTESTINE	SYCE3 →	-0.726	-1.543	.001	<.001	3	3
BREAST	IL1R1 →	-1.957	-1.142	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RALGPS2 by Regulation of antimicrobial peptide production activity — BREAST

Explore this box plot interactively →