Antibacterial peptide production

Across TCGA patient cohorts, RNA activity of the Antibacterial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP27, KLK7, and LAMB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial peptide production activity versus ARHGAP27 in GBM (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP27 →	+0.389	+0.541	<.001	<.001	3	7
HNSC	KLK7 →	+1.464	+0.209	<.001	<.001	3	6
PDAC	LAMB1 →	-0.288	-0.166	<.001	<.001	3	6
GBM	HTATIP2 →	+0.688	+0.724	<.001	<.001	3	5
HNSC	C6orf132 →	+0.633	+0.187	<.001	<.001	3	5
HNSC	CEP170_S1165 →	-0.426	-0.167	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002778 vs ARHGAP27 — GBM

Explore this scatter interactively →