Antibacterial peptide production

Across TCGA patient cohorts, RNA activity of the Antibacterial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAK3, CYP2C18, and RAB39A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial peptide production activity versus JAK3 in LUAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	JAK3 →	-0.701	-0.813	<.001	.002	3	4
HNSC	CYP2C18 →	+1.018	+0.709	<.001	<.001	3	3
LUAD	RAB39A →	-0.475	-0.714	<.001	<.001	3	3
LUAD	ST6GAL1 →	-0.557	-0.798	.002	.001	3	3
HNSC	SLPI →	+1.913	+1.085	<.001	<.001	3	3
LSCC	AQP3 →	+1.532	+0.805	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002778 vs JAK3 — LUAD

Explore this scatter interactively →