Antibacterial peptide production

Across TCGA cell cohorts, RNA activity of the Antibacterial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPRE1, RPSA, and SMS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial peptide production activity versus MAPRE1 in OVARY (Pearson r = -0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAPRE1 →	-1.278	-1.395	<.001	<.001	3	6
OVARY	RPSA →	-1.752	-1.553	<.001	<.001	3	6
LARGE_INTESTINE	SMS →	-1.073	-1.292	<.001	.001	3	6
BLOOD_Leukemia	TBCB →	-0.448	-0.898	.003	.002	3	5
BLOOD_Leukemia	HAS1 →	-1.751	-1.719	.002	<.001	3	5
OVARY	PARK7 →	-1.278	-1.578	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002778 vs MAPRE1 — OVARY

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