Antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Antimicrobial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1, EPM2AIP1, and ABI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial peptide production activity versus TP53BP1 in OV (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TP53BP1 →	-0.245	-0.097	.008	.004	3	5
GBM	EPM2AIP1 →	-0.244	-0.513	<.001	<.001	3	5
GBM	ABI2 →	-0.341	-0.635	<.001	.001	3	5
GBM	HTATIP2 →	+0.615	+0.725	.001	<.001	3	5
HNSC	JUP →	+0.762	+0.222	<.001	<.001	3	5
HNSC	KLK7 →	+1.414	+0.228	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002775 vs TP53BP1 — OV

Explore this scatter interactively →