Antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Antimicrobial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK6, JAK3, and HAPLN3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial peptide production activity versus PTK6 in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTK6 →	+0.682	+0.827	<.001	<.001	3	3
LUAD	JAK3 →	-0.746	-0.819	<.001	.002	3	3
LUAD	HAPLN3 →	-0.792	-0.762	<.001	.004	3	3
LUAD	RAB39A →	-0.395	-0.587	<.001	.001	3	3
LUAD	PLEKHO1 →	-0.308	-0.501	.006	.006	3	3
HNSC	CNTLN →	-0.563	-0.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002775 vs PTK6 — HNSC

Explore this scatter interactively →