Antimicrobial peptide production

Across TCGA patient cohorts, RNA activity of the Antimicrobial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9_T113, EXPH5_S341, and C1orf116, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial peptide production activity versus S100A9_T113 in UCEC (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S100A9_T113 →	+0.891	+0.210	<.001	<.001	2	4
HNSC	EXPH5_S341 →	+0.704	+0.841	<.001	<.001	3	3
HNSC	C1orf116 →	+0.656	+0.932	<.001	<.001	3	3
HNSC	EVPL →	+0.914	+1.022	<.001	<.001	3	3
PDAC	EVPL_S361 →	+0.899	+0.224	<.001	<.001	3	3
HNSC	EVPL_S906 →	+1.270	+0.844	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002775 vs S100A9_T113 — UCEC

Explore this scatter interactively →