Antimicrobial peptide production

Across TCGA cell cohorts, RNA activity of the Antimicrobial peptide production pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB3, BID, and FUT10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASB3 grouped by Antimicrobial peptide production-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ASB3 →	+0.677	+1.225	.005	.007	3	4
SKIN	BID →	-0.696	-0.767	.001	.004	3	3
OESOPHAGUS	FUT10 →	+0.873	+1.611	.003	.001	3	3
KIDNEY	SSNA1 →	-0.785	-1.273	.001	.006	3	3
BONE	ITM2B →	+1.990	+1.871	.006	<.001	2	4
SOFT_TISSUE	CPLANE1 →	-0.548	-1.223	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASB3 by Antimicrobial peptide production activity — BONE

Explore this box plot interactively →