Antimicrobial peptide production

Across TCGA cell cohorts, RNA activity of the Antimicrobial peptide production pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPSA, MAPRE1, and SMS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antimicrobial peptide production activity versus RPSA in OVARY (Pearson r = -0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPSA →	-1.752	-1.553	<.001	<.001	3	6
OVARY	MAPRE1 →	-1.278	-1.395	<.001	<.001	3	6
LARGE_INTESTINE	SMS →	-1.073	-1.292	<.001	.001	3	6
LARGE_INTESTINE	SLIT1 →	+0.713	+1.242	<.001	<.001	3	5
BREAST	CTNND1 →	+1.336	+1.417	<.001	.003	3	5
BLOOD_Leukemia	RPN1 →	+0.756	+1.739	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002775 vs RPSA — OVARY

Explore this scatter interactively →