Immune response-inhibiting signal transduction

Across TCGA patient cohorts, RNA activity of the Immune response-inhibiting signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, DOCK8, and HCLS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune response-inhibiting signal transduction activity versus SAMSN1_S23 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMSN1_S23 →	+0.760	+0.085	<.001	<.001	3	10
GBM	DOCK8 →	+0.530	+0.176	<.001	<.001	3	10
GBM	HCLS1 →	+0.662	+0.165	<.001	<.001	3	10
GBM	LCP2 →	+0.582	+0.170	<.001	<.001	3	10
GBM	LSP1 →	+0.721	+0.160	<.001	<.001	3	10
GBM	ARHGAP15 →	+0.644	+0.162	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002765 vs SAMSN1_S23 — LSCC

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