Regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR65, CIITA, and BIN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid leukocyte differentiation activity versus GPR65 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPR65 →	+1.025	+0.298	<.001	<.001	3	10
HNSC	CIITA →	+0.895	+0.226	<.001	<.001	3	9
GBM	BIN2 →	+0.770	+0.306	<.001	<.001	3	9
UCEC	CD3E →	+0.987	+0.220	<.001	<.001	3	9
UCEC	TRG-AS1 →	+0.538	+0.167	.005	.005	3	9
GBM	BTK →	+0.835	+0.264	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002761 vs GPR65 — GBM

Explore this scatter interactively →