Regulation of myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEN1, NET1, and HLA-DRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid leukocyte differentiation activity versus MEN1 in BONE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MEN1 →	-0.697	-0.465	.009	.002	3	4
LUNG_NSCLC_LUAD	NET1 →	-0.704	-0.556	.008	<.001	3	4
BLOOD_Leukemia	HLA-DRA →	+3.835	+0.225	.003	.002	3	4
LARGE_INTESTINE	MRPL24 →	-0.541	-0.891	.002	.001	3	4
LUNG_NSCLC_LUAD	MALL →	-2.865	-0.755	<.001	.001	3	4
LUNG_NSCLC_LUAD	POLB →	-0.987	-0.491	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002761 vs MEN1 — BONE

Explore this scatter interactively →