Regulation of antimicrobial humoral response

Across TCGA patient cohorts, RNA activity of the Regulation of antimicrobial humoral response pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNM2, CLIC3, and PRUNE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of antimicrobial humoral response activity versus DNM2 in LUAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNM2 →	+0.196	+0.081	<.001	<.001	3	5
HNSC	CLIC3 →	+0.795	+0.148	<.001	<.001	3	5
LSCC	PRUNE1 →	-0.355	-0.101	.001	<.001	3	5
GBM	RIPK3 →	+0.433	+0.489	<.001	.003	3	4
GBM	RND3 →	+0.342	+0.390	.002	.005	3	4
GBM	ZC2HC1A_S223 →	-0.840	-0.269	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002759 vs DNM2 — LUAD

Explore this scatter interactively →