Regulation of antimicrobial humoral response

Across TCGA cell cohorts, RNA activity of the Regulation of antimicrobial humoral response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMOTL2, GOLGB1, and CD59, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMOTL2 grouped by Regulation of antimicrobial humoral response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AMOTL2 →	-2.208	-1.840	.008	<.001	3	3
SKIN	GOLGB1 →	-0.461	-1.003	.002	.003	3	3
SKIN	CD59 →	-1.062	-0.998	.002	.003	3	3
BLOOD_Myeloma	TRIOBP →	+1.086	+1.596	.002	.006	3	3
BLOOD_Myeloma	PIGU →	+0.438	+2.141	.008	<.001	3	3
BLOOD_Leukemia	TTLL7 →	-1.074	-1.101	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMOTL2 by Regulation of antimicrobial humoral response activity — OVARY

Explore this box plot interactively →