Cytoplasmic pattern recognition receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Cytoplasmic pattern recognition receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM144, VAMP3, and GPAT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic pattern recognition receptor signaling pathway activity versus TMEM144 in LUNG_SCLC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM144 →	-0.999	-0.137	.006	.009	2	6
BLOOD_Leukemia	VAMP3 →	-0.382	-0.110	.008	.006	3	4
BLOOD_Leukemia	GPAT3 →	-1.349	-0.166	.002	.005	3	4
LUNG_NSCLC_LUSC	RFFL →	-1.020	-0.182	.001	.009	3	4
BONE	STARD3 →	-1.272	-0.244	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	XCL1 →	+1.042	+0.260	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002753 vs TMEM144 — LUNG_SCLC

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