Positive regulation of T cell cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, PSMB8, and HLA-A, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell cytokine production activity versus PSMB9 in BREAST (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PSMB9 →	+3.804	+1.950	<.001	<.001	3	13
SOFT_TISSUE	PSMB8 →	+4.398	+1.013	<.001	.007	3	12
BREAST	HLA-A →	+3.547	+1.771	<.001	<.001	3	12
BREAST	B2M →	+2.372	+2.048	<.001	<.001	3	12
BONE	HLA-B →	+5.672	+1.640	.001	.009	3	11
BREAST	PML →	+1.332	+1.459	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002726 vs PSMB9 — BREAST

Explore this scatter interactively →