Negative regulation of T cell cytokine production

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, THEMIS2_T593, and CD4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell cytokine production activity versus SAMSN1_S23 in UCEC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1_S23 →	+1.121	+0.130	<.001	<.001	3	10
UCEC	THEMIS2_T593 →	+0.846	+0.107	<.001	<.001	3	10
LSCC	CD4 →	+0.598	+0.076	<.001	<.001	3	10
UCEC	CD48 →	+1.081	+0.094	<.001	<.001	3	10
OV	CD53 →	+0.700	+0.056	<.001	<.001	3	10
OV	EVI2B_S268 →	+1.063	+0.068	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002725 vs SAMSN1_S23 — UCEC

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