Negative regulation of T cell cytokine production

Across TCGA patient cohorts, RNA activity of the Negative regulation of T cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, ADGRE2, and ITGAX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell cytokine production activity versus MEFV in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MEFV →	+0.609	+0.716	<.001	<.001	3	7
GBM	ADGRE2 →	+0.640	+0.544	<.001	.003	3	7
LUAD	ITGAX →	+0.673	+0.865	<.001	<.001	3	7
BRCA	THEMIS2 →	+0.898	+0.472	<.001	.006	3	7
PDAC	CSF3R →	+0.955	+0.736	<.001	<.001	3	6
UCEC	CCRL2 →	+0.882	+0.654	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002725 vs MEFV — LUAD

Explore this scatter interactively →