Negative regulation of T cell cytokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM35, MZT1, and RNF126, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM35 grouped by Negative regulation of T cell cytokine production-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM35 →	+1.032	+1.181	<.001	.005	3	4
BLOOD_Leukemia	MZT1 →	-1.209	-1.046	<.001	.007	3	4
STOMACH	RNF126 →	+0.856	+1.716	.002	<.001	3	4
BLOOD_Lymphoma	CCAR2 →	+0.857	+1.690	.004	<.001	3	3
BLOOD_Lymphoma	EZR →	-1.702	-1.739	.003	<.001	3	3
LUNG_SCLC	EXTL3 →	+2.002	+1.422	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM35 by Negative regulation of T cell cytokine production activity — LUNG_SCLC

Explore this box plot interactively →