Negative regulation of T cell cytokine production

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell cytokine production pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPNS1, H2BC17, and PLRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPNS1 grouped by Negative regulation of T cell cytokine production-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAPNS1 →	-0.264	-1.876	.001	<.001	3	5
LARGE_INTESTINE	H2BC17 →	-0.536	-1.058	.002	.003	3	4
BONE	PLRG1 →	-0.506	-1.546	.003	.002	3	4
OVARY	ITPA →	+0.252	+0.954	.002	.009	3	4
OESOPHAGUS	ZNF648 →	+0.180	+1.100	.001	.008	3	4
CNS	PSMB6 →	-0.332	-0.606	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPNS1 by Negative regulation of T cell cytokine production activity — BONE

Explore this box plot interactively →